We are seeking an experienced, strategic, and scientifically rigorous Medicinal Chemistry Leader to join our Research organization. The successful candidate will play a key role in advancing discovery programs from target validation through candidate selection, working within highly collaborative cross‐functional teams across chemistry, biology, DMPK, safety, and translational sciences.
The ideal candidate will bring deep expertise in small molecule drug discovery, with a demonstrated track record of leading medicinal chemistry programs from hit identification to preclinical candidate selection. Experience with emerging therapeutic modalities, including targeted protein degradation (PROTACs), oligonucleotides, peptides, or other beyond‐rule‐of‐5 modalities is highly desirable.
This role requires strong scientific leadership, strategic thinking, excellent communication skills, and the ability to thrive in a dynamic, matrixed research environment.
Key Responsibilities Lead medicinal chemistry efforts across one or more discovery programs from concept through candidate selection.




Drive the design, synthesis, and multiparameter optimization of novel compounds, effectively integrating computational insights and data‐driven SAR/SPRs to optimize potency, selectivity, ADME/PK, and safety profiles.
Serve as a scientific leader within multidisciplinary project teams, partnering closely with biology, DMPK, pharmacology, toxicology, translational sciences, and computational chemistry colleagues to define project strategies and Target Product Profiles.
Apply innovative approaches and new technologies to accelerate drug discovery. Embrace advanced chemistry technologies, including automation‐enabled workflows, generative AI, and digital design tools as well as new advanced modalities such as chemical induced proximity.
Manage and oversee external CRO chemistry activities to ensure timely, rigorous execution and alignment with project objectives.
Contribute to scientific assessmen

📌 Scientist - Chemistry (Italia)
🏢 Angelini Pharma
📍 Italia