ph3Researcher bridging immunology, genomics and proteomics (academic-industry collaboration) /h3 pUniversity of Oslo – Department of Immunology, Division of Laboratory Medicine, Institute of Clinical Medicine. /p pPosition: Two‑year researcher (SKO 1109). Start date: July‑September 2026, flexible. Full‑time, located at GSK Vaccines S.r.l., Siena, Italy (MS Structural Biology, Ab Discovery and Immunology unit). Scientific advisor: Dr. Greiff, Lab for Computational and Systems Immunology. /p pThe role focuses on developing an Ig‑seq platform to integrate B‑cell receptor (BCR) repertoire sequencing with serology and LC‑MS/MS proteomics for immunoproteogenomics. The candidate will design, implement, and perform experiments, data analysis, and computational modelling to link B‑cell clonotypes to serum antibodies and resolve functional proteoforms. /p h3More about the position /h3 pProject aims: investigate polyclonal humoral responses to a model viral antigen in humans, using antigen‑specific B‑cell sorting, BCR sequencing, LC‑MS/MS identification of circulating antigen‑specific antibodies, de‑novo sequencing workflows, proteogenomic pipelines, and machine learning for antibody identification and epitope prioritisation. /p pResponsibilities include development and analysis of mass spectrometry methods for antibody isolation and characterisation, designing multiparameter flow‑cytometry panels for antigen‑specific B‑cells and plasma cells, rigorous data stewardship, collaboration across immunology, proteomics, and bioinformatics teams, mainly at GSK Siena, and dissemination of research findings. /p h3Key Duties /h3 ul liBCR library preparation and sequencing workflows. /li liImplementing bioinformatics pipelines for clonotyping, lineage tracing, and proteogenomic integration.



/li liPerforming comparative analyses with published datasets. /li /ul h3Qualifications /h3 pAppointment requires a doctoral degree in Proteomics. /p ul liHands‑on experience with LC‑MS/MS method development for proteins/antibodies, including sample preparation, instrument set‑up, and troubleshooting. /li liProficiency in Python and/or R and scientific computing, reproducible research practices (Git, containers, workflows). /li liAbility to build and run bioinformatics pipelines (de‑novo peptide sequencing, spectral annotation, FDR control). /li liExcellent written and oral communication skills in English. /li /ul h3Desired qualifications /h3 ul liExpertise in immune receptor immunology (BCR/TCR) and repertoire analytics (clonotyping, lineage tracing, SHM, germline inference). /li liExperience with BCR repertoire analysis (bulk and/or single cell). /li liExperience with advanced Flow Cytometry and Cell Sorting. /li liStructural biology/protein informatics related to antibody‑antigen interactions and developability assessment. /li liExperience with complementary fragmentation methods (HCD/ETD/EThcD), intact/middle‑down workflows, and disulfide/glycoform mapping. /li liHigh‑performance/parallel computing; familiarity with ML frameworks (PyTorch/TensorFlow) and benchmarking. /li liPrior experience integrating proteomics and repertoire sequencing (immunoproteogenomics). /li /ul h3Personal skills /h3 ul liCollaborative,



adaptable, effective in interdisciplinary, ambitious environment. /li liIndependent, solution‑oriented, organised; strong scientific rigor and documentation practices. /li /ul h3We need different perspectives in our work /h3 pUiO is an inclusive, diverse university. We accommodate needs, including adjustments to working hours, task adaptations, digital, technical, or physical adjustments. /p h3We offer /h3 ul liExciting, meaningful tasks in an organization with an important societal mission. /li liScientific, interdisciplinary, international environment at GSK Siena with state‑of‑the‑art proteomics and flow‑cytometry facilities. /li liMentorship by Prof. Victor Greiff and collaboration across immunology, proteomics, and computational teams. /li liProfessional development, training, and conference participation. /li liCommitted colleagues in a good working environment. /li liGood welfare schemes. /li liOpportunity of up to 1.5 hours a week of exercise during working hours. /li liWorkplace with good development and career opportunities. /li liMembership in the Statens Pensjonskasse – a leading pension scheme with beneficial mortgages and insurance schemes. /li liSalary for Researcher (code 1109) in the range NOK 640,000 – 760,000, depending on competence and experience (2% deducted for statutory pension contributions). /li /ul h3General information /h3 pThe best qualified candidates will be invited for interviews. Applicant lists may be published in accordance with Norwegian Freedom of Information Act § 25. Exemption from publication can be requested; justification is required. Please refer to rules for use of research posts SKO 1108, 1109, 1110, 1183 at UiO. /p /p #J-18808-Ljbffr

📌 Researcher bridging immunology, genomics and proteomics (academic-industry collaboration) (Italia)
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