ph3Researcher bridging immunology, genomics and proteomics (academic-industry collaboration) /h3 pApplicants are invited to apply for a two-year Researcher position (SKO 1109) in immuno-proteomics (hands‑on biology). The position is based at the Department of Immunology, Division of Laboratory Medicine, Institute of Clinical Medicine, University of Oslo. /p pThe position is available from July 2026 with a flexible start date between July and September 2026. It is a full‑time role physically based at GSK Vaccines S.r.l. in Siena, Italy, within the MS Structural Biology, Ab Discovery and Immunology unit. Scientific advising and guidance will be provided by Dr. Greiff (Lab for Computational and Systems Immunology, greifflab.org). /p pThe researcher will develop and establish an Ig‑seq platform bridging immunoglobulin profiling, B‑cell receptor (BCR) repertoire sequencing and serology. /p h3More about the position /h3 pThe proposed project aims to investigate the polyclonal humoral immune response to a model viral antigen in human samples from pre‑exposed individuals. This research integrates advanced techniques, including antigen‑specific B‑cell sorting, B‑cell receptor (BCR) sequencing, and LC‑MS/MS‑based identification of circulating antigen‑specific antibodies. The goal is to link B‑cell clonotypes to serum immunoglobulins and resolve functional proteoforms through an immunoproteogenomics approach. The project will involve developing de novo sequencing workflows for antigen‑specific antibodies, building proteogenomic pipelines to assemble VH/VL sequences and identify clonotypes. Data will be integrated matching BCR repertoires of PBMCs, tonsil tissue, and matched sera from GSK human biological samples. Computational modeling and machine learning will be essential for antibody identification, epitope prioritization, and cross‑cohort comparisons. /p pThe project focuses on deconvoluting pathogen‑specific humoral responses to a seasonal viral pathogen by combining paired BCR repertoire sequencing with antigen‑resolved LC‑MS/MS proteomics. The candidate's responsibilities will encompass the development and analysis of mass spectrometry methods for antibody isolation and characterization, as well as designing and validating multiparameter flow cytometry panels for antigen‑specific B‑cell and plasma cell identification and sorting. The role demands rigorous data stewardship, collaboration with immunology, proteomics, and bioinformatics teams, primarily at GSK Siena, and contributing to the dissemination of research findings.



/p h3Key Duties /h3 ul liBCR library preparation and sequencing workflows /li liImplementing bioinformatics pipelines for clonotyping, lineage tracing, and proteogenomic integration /li liPerforming comparative analyses with published datasets /li /ul h3Qualifications /h3 pbQualification requirements /b /p ul liDoctoral degree in Proteomics /li liHands‑on experience with LC‑MS/MS method development for proteins/antibodies, including sample preparation, instrument setup, and troubleshooting /li liProficiency in Python/R and scientific computing, and reproducible research practices (Git, containers/workflows) /li liAbility to build and run bioinformatics pipelines (de novo peptide sequencing, spectral annotation, FDR control) /li liExcellent written and oral communication skills in English /li /ul pbDesired qualifications /b /p ul liExpertise in immune receptor immunology (BCR/TCR) and repertoire analytics (clonotyping, lineage tracing, SHM, germline inference) /li liExperience with BCR repertoire analysis (Bulk and/or single cell) /li liExperience with advanced Flow Cytometry and Cell Sorting /li liStructural biology/protein informatics relevant to antibody‑antigen interactions and developability assessment /li liExperience with complementary fragmentation methods (HCD/ETD/EThcD), intact/middle‑down workflows, and disulfide/glycoform mapping /li liHigh‑performance/parallel computing; familiarity with ML frameworks (PyTorch/TensorFlow) and benchmarking /li liPrior experience integrating proteomics and repertoire sequencing (immunoproteogenomics) /li /ul h3Personal skills /h3 ul liCollaborative, adaptable, and effective in an interdisciplinary, ambitious environment /li liIndependent, solution‑oriented, and organised; strong scientific rigor and documentation practices /li /ul h3We need different perspectives in our work /h3 pUiO is an open and internationally oriented comprehensive university that strives to be an inclusive and diverse workplace and academic environment. We fulfill our mission most effectively when we draw upon our variety of experiences, backgrounds, and perspectives. We will do our best to accommodate your needs. Relevant adjustments may include modifications to working hours, task adaptations, digital, technical, or physical adjustments, or other practical measures. /p pIf you have an immigrant background,



a disability, or CV gaps, we encourage you to indicate this in the job application portal. In this context, disability is defined as an applicant who identifies as having a disability that requires workplace or employment‑related accommodations. /p h3We offer /h3 ul liExciting and meaningful tasks in an organization with an important societal mission, contributing to knowledge development, education, and enlightenment that promote sustainable, fair, and knowledge‑based societal development /li liA scientifically rich, interdisciplinary and international environment at GSK Siena with access to state‑of‑the‑art proteomics and flow cytometry facilities /li liAdvising and mentorship by Prof. Victor Greiff; opportunities for collaboration across immunology, proteomics, and computational teams /li liProfessional development, training, and conference participation /li liCommitted colleagues in a good working environment /li liA workplace with good development and career opportunities /li liMembership in the Statens Pensjonskasse, which is one of Norway's best pension schemes with beneficial mortgages and good insurance schemes /li liSalary in position as Researcher, position code 1109 in salary range NOK from 640,000 to 760,000, depending on competence and experience. From the salary, 2 percent is deducted in statutory contributions to the State Pension Fund /li /ul h3Application /h3 pYour application should include: /p ul liCV /li liA complete list of publications /li liProject/research plan aligned with the position scope /li liTranscripts and certificates /li liContact information for 2–3 references /li /ul pApplication with attachments must be submitted via our recruitment system Jobbnorge, click "Apply for the position". /p pWhen applying for the position, we ask you to retrieve your education results from Vitnemålsportalen.no. If your education results are not available through Vitnemålsportalen, we ask you to upload copies of your transcripts or grades. Please note that all documentation must be in English or a Scandinavian language. /p h3General information /h3 pThe best qualified candidates will be invited for interviews. /p pApplicant lists can be published in accordance with Norwegian Freedom of Information Act § 25. When you apply for a position with us, your name will appear on the public applicant list. It is possible to request to be excluded from this list. You must justify why you want an exemption from publication and we will then decide whether we can grant your request. If we cannot, you will hear from us. /p /p #J-18808-Ljbffr

📌 Researcher bridging immunology, genomics and proteomics (academic-industry collaboration) (Siena)
🏢 Uiodoc
📍 Siena