About The PositionApplicants are invited to apply for a two‑year Researcher position (SKO 1109) in immuno‑proteomics (hands‑on biology). The position is based at the Department of Immunology, Division of Laboratory Medicine, Institute of Clinical Medicine, University of Oslo.

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More About The PositionThe researcher will develop and establish an Ig‑seq platform bridging immunoglobulin profiling, B‑cell receptor (BCR) repertoire sequencing and serology. The proposed project aims to investigate the polyclonal humoral immune response to a model viral antigen in human samples from pre‑exposed individuals. It integrates antigen‑specific B‑cell sorting, B‑cell receptor (BCR) sequencing and LC‑MS/MS‑based identification of circulating antigen‑specific antibodies. The goal is to link B‑cell clonotypes to serum immunoglobulins and resolve functional proteoforms through an immunoproteogenomics approach.



The research involves developing de‑novo sequencing workflows for antigen‑specific antibodies, building proteogenomic pipelines, and performing computational modeling and machine learning for antibody identification, epitope prioritization and cross‑cohort comparisons.
Key Duties
- BCR library preparation and sequencing workflows.
- Implementing bioinformatics pipelines for clonotyping, lineage tracing, and proteogenomic integration.
- Performing comparative analyses with published datasets.

Qualification Requirements
- Doctoral degree in proteomics.
- Hands‑on experience with LC‑MS/MS method development for proteins/antibodies, including sample preparation, instrument setup and troubleshooting.
- Proficiency in Python/R, scientific computing and reproducible research practices (Git, containers/workflows).
- Ability to build and run bioinformatic pipelines for de‑novo peptide sequencing, spectral annotation and FDR control

📌 Researcher bridging immunology, genomics and proteomics (Siena)
🏢 University of Oslo
📍 Siena