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Deciphering the Functional Role of a Three-miRNA Signature in Glioma From Molecular Mechanisms to Potential Clinical Application

Led by Regina Elena Cancer Institute

Updated on 2026-06-05

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R

Regina Elena Cancer Institute

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U

University of Roma La Sapienza

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What This Trial Is About

Researchers are investigating the role of a specific three-miRNA signaturemiR-1-3p, miR-26a-1-3p, and miR-487b-3pin glioma, a type of brain tumor. This study focuses on how these miRNAs affect tumor cell behavior, including cell viability, proliferation, migration, and invasion, particularly in grade III and higher grade IDH-wild type glioma cells.



The research also explores how these miRNAs might influence the tumors response to treatments like radiotherapy and temozolamide, aiming to better understand the biology of gliomas and potential clinical applications. The study uses glioma cell lines and primary cells derived from patients, categorized by molecular and immunohistochemical features according to the 2016 WHO classification. Researchers apply gain and loss of function methods to assess the effects of the miRNA signature on the tumor cells. They will evaluate cellular sensitivity to radiotherapy and temozolamide by creating dose-response curves in both IDH-wild type and IDH-mutated glioma cells over a 36-month period. Participants contribute surgical tissue samples for analysis, enabling detailed study of the miRNA signatures impact on tumor biology. The primary outcome measured is the dose-response to treatments over three years. This observational study does not involve administering treatments directly but foc

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