Scope of the Role

Within the Global Commercial Operations & Execution Team, the Regional RX Commercial Operations Lead is accountable for accelerating the global development and in-market performance of the Prescription Medicines portfolio, working in close partnership with country organizations.

The role acts as a senior Global–Local commercial leader, ensuring alignment with global brand and franchise strategies for strategic products, while enabling superior country planning, launch execution and sustained in-market performance.

Covering established and innovative products across primary care, specialty care, hospital and rare disease segments, the role requires a deep understanding of local market dynamics, regulatory and market access environments, and complex stakeholder ecosystems, and plays a critical role in building long-term commercial capabilities across RX markets.

What will you do

- Provide global commercial leadership to RX markets, working closely with Country General Managers and local RX leadership teams to drive performance, accountability and execution excellence across the portfolio
- Act as a senior strategic partner to country organizations, supporting and challenging country business plans, launch strategies and key commercial initiatives to ensure alignment with global priorities and local market realities
- Serve as the primary two-way Global–Local interface, translating global franchise, brand and go-to-market strategies into integrated, executable country plans, while channeling structured market insights, risks and opportunities back to Global teams
- Oversee ongoing execution and performance management across the RX portfolio, monitoring progress against agreed country plans, driving corrective actions where needed and ensuring disciplined, structured performance management across markets.
- Support launch excellence for strategic RX assets across countries,



in line with global strategies, by providing senior oversight and hands-on support on launch readiness, sequencing, execution quality and post-launch optimization.
- Develop a deep, ground-level understanding of market dynamics, including competitive landscape, treatment paradigms, pricing & reimbursement environments and stakeholder needs (HCPs, payers, institutions), leveraging country insights to inform portfolio and lifecycle decisions
- Identify and address commercial capability gaps across countries, acting as an enabler for RX markets by developing targeted capability-building initiatives in partnership with Global Capability lead
- Represent country and regional needs towards Global Franchises and Corporate functions, influencing global strategy, investment prioritization and operating model choices based on real-world execution experience
- Partner with the Global Non-Strategic Portfolio PMO to identify, assess and prioritize opportunities within the non-strategic RX portfolio, supporting robust business case development with strong country input
- Champion innovation and continuous improvement, promoting best practice sharing across countries and driving initiatives to enhance commercial effectiveness, launch excellence and operational efficiency

Who are you

Professional Experience

- Minimum 12–15 years of progressive leadership experience within the pharmaceutical RX environment
- Proven success in senior commercial leadership roles (e.g. Business Unit Head,



Country Commercial Head, Global or Regional Commercial Lead), with strong exposure to country-level execution
- Demonstrated executive-level P&L; ownership, including strategic planning, performance delivery and resource prioritization
- Strong track record of multiple successful RX launches, ideally across different markets and therapeutic areas
- Solid experience operating in global matrix organizations, with the ability to influence and lead country teams without direct reporting lines

Education

- Bachelor’s degree in Pharmacy, Life Sciences, Business or related disciplines
- MBA or equivalent executive education strongly preferred

Key Skills & Leadership Capabilities

- Deep understanding of RX commercial models and country-level execution dynamics, including regulatory frameworks, pricing & reimbursement and access complexity
- Ability to combine global strategic thinking with strong local market orientation
- Proven capability to lead, influence and align country leadership teams across geographies and cultures
- Excellent executive communication and stakeholder management skills, spanning Global Franchises, Local Leadership Teams and Corporate functions
- Strong financial and analytical acumen, leveraging qualitative and quantitative insights to guide decisions
- Expertise in brand strategy implementation, launch governance and execution monitoring
- Demonstrated ability to build sustainable commercial capabilities across markets

Salary Range: €130000 - €150000

The salary range indicated in this job posting represents the minimum and maximum compensation range for the position. Final compensation will be determined based on the selected candidate's experience, skills, and qualifications, in accordance with the EU Pay Transparency Directive (Directive (EU) 2023/970).

📌 VP, Regional RX (Prescription Medicines) Commercial Operations Lead (Milano)
🏢 ALFASIGMA
📍 Milano