Within the Global Commercial Operations & Execution Team, the Regional RX Commercial Operations Lead is accountable for accelerating the global development and in-market performance of the Prescription Medicines portfolio, working in close partnership with country organizations.
The role acts as a senior Global–Local commercial leader, ensuring alignment with global brand and franchise strategies for strategic products, while enabling superior country planning, launch execution and sustained in-market performance.
Covering established and innovative products across primary care, specialty care, hospital and rare disease segments, the role requires a deep understanding of local market dynamics, regulatory and market access environments, and complex stakeholder ecosystems, and plays a critical role in building long-term commercial capabilities across RX markets.
What will you do
Provide global commercial leadership to RX markets, working closely with Country General Managers and local RX leadership teams to drive performance, accountability and execution excellence across the portfolio
Act as a senior strategic partner to country organizations, supporting and challenging country business plans, launch strategies and key commercial initiatives to ensure alignment with global priorities and local market realities
Serve as the primary two-way Global–Local interface, translating global franchise, brand and go-to-market strategies into integrated, executable country plans, while channeling structured market insights, risks and opportunities back to Global teams
Oversee ongoing execution and performance management across the RX portfolio, monitoring progress against agreed country plans, driving corrective actions where needed and ensuring disciplined, structured performance management across markets.
Support launch excellence for strategic RX assets across countries,



in line with global strategies, by providing senior oversight and hands?on support on launch readiness, sequencing, execution quality and post?launch optimization.
Develop a deep, ground-level understanding of market dynamics, including competitive landscape, treatment paradigms, pricing & reimbursement environments and stakeholder needs (HCPs, payers, institutions), leveraging country insights to inform portfolio and lifecycle decisions
Identify and address commercial capability gaps across countries, acting as an enabler for RX markets by developing targeted capability?building initiatives in partnership with Global Capability lead
Represent country and regional needs towards Global Franchises and Corporate functions, influencing global strategy, investment prioritization and operating model choices based on real?world execution experience
Partner with the Global Non?Strategic Portfolio PMO to identify, assess and prioritize opportunities within the non?strategic RX portfolio, supporting robust business case development with strong country input
Champion innovation and continuous improvement, promoting best practice sharing across countries and driving initiatives to enhance commercial effectiveness, launch excellence and operational efficiency
Who are you
Professional Experience
Minimum ***** years of progressive leadership experience within the pharmaceutical RX environment
Proven success in senior commercial leadership roles (e.g. Business Unit Head,



Country Commercial Head, Global or Regional Commercial Lead), with strong exposure to country?level execution
Demonstrated executive?level P&L; ownership, including strategic planning, performance delivery and resource prioritization
Strong track record of multiple successful RX launches, ideally across different markets and therapeutic areas
Solid experience operating in global matrix organizations, with the ability to influence and lead country teams without direct reporting lines
Education
Bachelor's degree in Pharmacy, Life Sciences, Business or related disciplines
MBA or equivalent executive education strongly preferred
Key Skills & Leadership Capabilities
Deep understanding of RX commercial models and country?level execution dynamics, including regulatory frameworks, pricing & reimbursement and access complexity
Ability to combine global strategic thinking with strong local market orientation
Proven capability to lead, influence and align country leadership teams across geographies and cultures
Excellent executive communication and stakeholder management skills, spanning Global Franchises, Local Leadership Teams and Corporate functions
Strong financial and analytical acumen, leveraging qualitative and quantitative insights to guide decisions
Expertise in brand strategy implementation, launch governance and execution monitoring
Demonstrated ability to build sustainable commercial capabilities across markets
The salary range indicated in this job posting represents the minimum and maximum compensation range for the position.
Final compensation will be determined based on the selected candidate's experience, skills, and qualifications, in accordance with the
EU Pay Transparency Directive (Directive (EU) ********)
.
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📌 Vp, Regional Rx (Prescription Medicines) Commercial Operations Lead (Milano)
🏢 ALFASIGMA
📍 Milano