**Human Technopole (HT)**is an interdisciplinary life science research institute, created and supported by the Italian Government, with the aim of developing innovative strategies to improve human health. HT is composed of five Centers: Neurogenomics, Computational Biology, Structural Biology, Genomics, and Health Data Science. The Centers work together to enable interdisciplinary research and to create an open, collaborative environment that will help promote life science research both nationally and internationally. **About the lab and project** Thyroid hormones are essential to drive metabolism and development. In humans, thyroid disfunction severely impacts cardiovascular homeostasis, metabolism, brain development and function, with increasing incidence Worldwide. We aim at characterizing the structure and function of thyroid organelles and pathways (including cilia and trafficking routes) in cells, organoids and tissues, by integrating cell biology and structural biology methods (including advanced light microscopy, electron microscopy and expansion microscopy). In the long term, this research lays basis towards improving diagnosis and treatment of major thyroid disorders and their relationships with other diseases. Human Technopole gives us a great opportunity to reach this goal at The Centre for Structural Biology with an excellent, international environment and cutting-edge scientific facilities. You are welcome to get in touch for details on the project to francesca.coscia[at]fht.org **See previous work on the research topics of this call**:




**Key tasks and responsibilities**: - Maintaining cell cultures for functional and structural analysis in the respect of common lab policies and procedures, collaborating with the members of the team.
- Developing and sharing methods with the laboratory using digital notebooks.
- Reporting to the PI and at meetings by writing presentations and reports, aimed at publications. **Essential requirements**
- Experience with cell biology.
- Experience with quantitative light imaging.
- Experience in protein extraction and analysis, gene cloning and gene editing (e.g., knock down, use of viral vectors, cell lines). **Preferential requirements**
- These requirements are preferential, “nice to have”. The screening report will be based on these requirements.[FD1]
- Organoids culture and tissue sectioning
- Structural cell biology (advanced light microscopy, expansion microscopy and electron microscopy)
- Analysis of proteomics, RNA and DNA sequencing datasets **Other key competencies**
- Excellent English speaking and writing
- Proactive attitude to learn new methods and topics
- Excellent collaborative attitude in the laboratory **Application Instructions** To apply,



please send the following: - a CV.
- a motivation letter in English relating your track record to the specifics of the call.
- names and contacts of 2 referees. **Why Human Technopole** HT seeks scientific excellence, we recruit the best scientific talents through international, open calls. Our working environment is international, friendly and inclusive. Our scientists work together across disciplines on research topics of biomedical relevance, leveraging synergies between their diverse skillsets and methodological approaches. We believe that highly diverse teams yield the best and most innovative results. We engage in outward-facing scientific activities aimed at benefiting the national and international research community. Training is also at the heart of our activity, with initiatives and opportunities for our staff, including scientific courses, conferences and workshops. **Main benefits**
- Welfare plans.
- Canteen service.
- Work-life balance provisions.
- Italian language training for foreigners.
- Parental leave up to 1 year and other support for new parents.
- Counseling.
- Flexible working hours.
- Remote working policy.
- Researchers coming to Italy for the first time, or returning after residing abroad, agevolazioni from very attractive income tax benefits. Number of positions offered: 1 Contract offered: CCNL Chimico Farmaceutico, Fixed-term 4 years - Employee Level Tax benefits where applicable. The position is based in Milan. **_

📌 Postdoc in Cell Biology - Coscia Group (Milano)
🏢 Human Technopole
📍 Milano