Axxam is a leading provider of integrated discovery services for the entire Life Sciences industries such as Pharmaceutical, Crop protection, Animal health, Cosmetics and Nutrition. We have world-class expertise across a broad range of discovery disciplines and innovative technologies including assay development, compound management, high throughput screening, hit identification and hit validation. Axxam is also engaged in developing strategic partnerships aimed at generating novel innovative therapies for diseases with high unmet medical need. An open and dynamic working environment ensures high-quality results from the teams of scientists and other professionals conducting all the experimental activities, supported by an industrialized organization.

Senior Analytical Chemist:
We are currently seeking a highly motivated Senior Analytical Chemist, to join our Medicinal Chemistry Group based in Torre Annunziata - Naples. The candidate will support integrated small-molecule drug discovery programs through analytical chemistry, mass spectrometry, NMR and in vitro ADME, while also contributing to metabolite identification and the characterization of peptides and oligonucleotides and to broader ADME workflows.

RESPONSIBILITIES:
The successful candidate will be an experienced and dynamic scientist with a proven track record as an analytical chemist. The candidate is expected to work in a team led by the Head of the Hit & Lead Discovery group and in a multidisciplinary environment.

He/She will be familiar with the early steps of the integrated drug discovery process.

His or her responsibilities will include:
Analysis of samples from various sources;
Performance and interpretation of in vitro ADME assays, including at least chemical stability, solubility, microsomal stability, PAMPA permeability, Plasma Protein Binding and plasma stability assays;
Development and validation of HPLC methods for the analysis and the purification of compounds, including chiral separation;
Development and validation of highly sensitive and reliable LC/MS methodologies for qualitative and quantitative analysis;




Acquisition and interpretation of 1D and 2D NMR experiments for chemical structure elucidation;
Conduct peptide, oligonucleotide, and metabolite characterization studies using Orbitrap HRMS, including sample preparation, mass spectrometric analysis, data evaluation and interpretation, and comprehensive reporting of results; development and validation of new assays when required;
Preparation of method development reports for reliable, sensitive, and qualified analytical methods;
Preparation of summary reports and presentation of results to clients;
Ensuring that all work performed is performed effectively, efficiently and to the highest quality standard (GRP/GLP-Like/ISO Environment) within area of responsibility;
Partner with and support the Hit & Lead Discovery group during integrated programs;
Provides cross-functional support to other groups as required;
Actively undertake organizational responsibilities in lab organization, including maintaining equipment and implementation of new equipment;
Following safe working practices, complying with appropriate legislation and keeping appropriate laboratory records; Owns the accountability and responsibility of delivering to client needs and timeliness.

QUALIFICATION & SKILLS:
A PhD or Master’s degree in Biotechnology, Pharmacy, CTF, Chemistry;
Previous industrial experience (at least 6 years);
Proven expertise in analytical method development and validation;
A deep knowledge and practical experience of high-performance liquid chromatography, advanced mass spectrometry platforms (single quadrupole, triple quadrupole and high-resolution mass spectrometer), NMR and data processing software (Xcalibur, Chromeleon, TraceFinder, TopSpin, MestreNova);




Knowledge of AS-MS (Affinity Selection Mass Spectrometry) instrumentations and application;
Experience with automated liquid handling platforms instruments is considered a plus;
Experience in synthetic chemistry is considered a plus;
Time management skills;
Knowledge of laboratory automation software, chemistry software for analytical, and Microsoft application;
Ability to use IT systems to support laboratory operations e.g. literature searching;
Familiarity with GLP environments or similar, Axxam operates under a GRP/ISO Quality Environment with data integrity and security at the centre;
Good analytical, interpersonal and teamwork skills, precision, and flexibility;
Ability to manage activities with tight deadlines and high matrix complexity;
Consistent and reliable approach to work, diligent and precise management of activities;
Good written and spoken English.

Desirable individual characteristics should include:
Innovative and creative thinking;
Strong problem-solving skills;
A commitment to quality and scientific rigour;
Enthusiasm for generating knowledge from data;
Excellent team player;
Excellent analytical skills;
Excellent interpersonal skills, ability to develop productive relationships within the Axxam organization and with a range of international collaborators at external centres of scientific excellence.

Axxam is an equal opportunity employer

Axxam offers a stimulating work environment and a competitive salary. If your background and personal experience fit this profile, please send your complete application, including a brief description of your experience, your CV and a list of references to the address below or upload it at our on-line contact centre: http://www.axxam.com/careers/job-listing. Please, include subject (Ref.) in the message and add to your CV the following statement: "I hereby grant permission to use my personal data in accordance with the Italian Leg. Dec. 196/2003".

Axxam S.p.A.

Openzone - via Meucci 3 - 20091 Bresso (Milano, Italy)

Fax +39 02 2105602 – www.axxam.com

📌 Senior Analytical Chemist (Italia)
🏢 AXXAM
📍 Italia