The Ostuni lab combines advanced single-cell and spatial genomics on human samples with
mechanistic studies in the mouse to elucidate how microenvironmental factors shape the behavior
of innate immune cells. Over the years, we contributed to the understanding of the molecular control
and functional implications of macrophage and neutrophil diversity in homeostasis and cancer .
Our research has been published in top scientific journals and is funded by the most prestigious
agencies such as the European Research Council (ERC-StG, ERC-CoG, ERC-PoC). Our vision is that by taking an interdisciplinary approach to understand biology we will develop the next generation of cell and gene therapies for immune-mediated human diseases, such as cancer. In our group, wet-lab and computational scientists engage in a virtuous cycle whereby biology instructs data analysis and data analysis fuels experimental hypothesis.
We discovered a central pathogenetic mechanism driving inflammation and immune evasion in pancreatic cancer (PDAC),



fueled by the local interplay between a subset of IL-1b+ macrophages and tumor cells endowed with molecular features of aggressive disease ( Nature 2023 ).
We further developed state-of-the-art technologies for spatial gene expression analyses in human PDAC samples that enable in situ quantification of hundreds of transcripts with subcellular resolution. The successful applicant will build on these unique datasets and resources to elucidate the spatial dynamics and niche control of immune-stromal-tumor cell interactions in human cancer. Development of methods, pipelines, and tools for data analysis, as well as active engagement in multiple lab projects, is a key anticipated output of the research activity.
We offer a research collaboration contract with competitive salary, benefits, and training programs commensurate to experience and qualifications. International candidates will vantaggi from major tax deduction.
The successful applicant will be a member

📌 Bioinformatico (Milano)
🏢 San Raffaele Telethon Institute for Gene Therapy (SR-Tiget)
📍 Milano