Sibylla Biotech is seeking an outstanding, highly motivated senior project manager with experience in the biotech/pharmaceutical industry in oncology to join its multidisciplinary team in Bresso (MI), Italy. Sibylla is the exclusive licensee of an innovative technology named Pharmacological Protein Inactivation by Folding Intermediate Targeting (PPI-FIT), which enables the identification of small molecules that promote the degradation of a target protein by interfering with its folding pathway. This new technology paves the way for selective degradation of previously undruggable proteins.

Our computational platform enables the characterization of previously unexplored protein conformations (folding intermediates) that can be exploited as new drug targets. The company has an oncology pipeline, and its lead asset is approaching candidate nomination.

The role

We are looking for an experienced Project Manager to lead the planning and execution of our development programs, from early preclinical stages through clinical development and regulatory filing. Reporting to the COO and working closely with the leadership team and cross-functional teams, you will turn scientific strategy into integrated project plans and keep our assets moving toward their milestones on time and on budget.

Key responsibilities

- Build and maintain integrated project plans covering activities, resources, timelines, and costs for each asset.
- Coordinate cross-functional teams to deliver key milestones.
- Monitor progress, proactively identify risks related to timing, resources, and funding, and propose mitigation plans together with senior management
- Support the development and tracking of project budgets in collaboration with Finance.
- Organize and lead project meetings, prepare minutes, and follow up on actions.




- Produce periodic progress reports for senior management and maintain official project documentation.
- Support teams in preparing regulatory documentation and submissions.

What we're looking for

- Master's degree in Life Sciences (Biology, Pharmacology, Pharmacy, Biotechnology, or related field).
- At least 8-10 years of experience in pharmaceutical or biotech drug development, including at least 5 years in project management.
- Proven track record of managing projects across development stages
- Solid knowledge of the drug discovery and development process and of early clinical development
- Experience in oncology is strongly preferred.
- Proficiency with Microsoft Project, Business Map (or similar tools) and the Office suite.
- Fluent English, written and spoken

What We Offer

You will be part of a highly cross-disciplinary environment. Scientists in our company come from diverse scientific areas, such as theoretical physics, computer science, medicinal chemistry, and biology. You will have opportunities to break new ground. Our company is a fast-growing organization, offering excellent opportunities for advancement and promotions. You will be given responsibilities, and we will fully support your professional growth, always prioritizing your personal needs. Lastly, we offer a competitive salary ranging from 60k€ to 75k€ gross depending on your seniority, plus a premio and a welfare plan.

Sibylla

Biotech is an equal opportunity employer, and freedom from discrimination is a fundamental human right.

Hybrid position (HQ in Bresso with possibility of smart working).

Start of the activities: As soon as possible

How to apply

You can apply by email by sending your CV and a short cover letter to [email protected], copying [email protected], by October 8th, 2026.

Applications through the LinkedIn form will not be considered.

Please include your consent to the processing of personal data under GDPR (EU 2016/679).

📌 Project Manager – Drug Development (Oncology) (Milano)
🏢 Sibylla Biotech
📍 Milano