pbBuild the science that shapes the future of human health. /bbr/bApplication closing date: 08 November 2026 /b /p h3Join a place where ambitious science thrives /h3 pHuman Technopole (Milan) is a rapidly expanding life science institute where international researchers and cutting-edge technologies converge to accelerate biomedical discovery. Our mission is to transform bold scientific ideas into advances that improve human health. /p pWithin this mission, The Structural Proteomics Unit studies protein structure and interactions using advanced mass spectrometry–based proteomics, with a strong focus on crosslinking MS and high-throughput workflows, including single-cell proteomics. It operates state-of-the-art instrumentation and advanced data analysis pipelines within the multidisciplinary ecosystem of Human Technopole. the Proteomics Specialist will report to the Unit Manager and collaborate closely with National Facilities and research groups. The focus of the Proteomics Specialist will be to support high throughput proteomics of cell lines, organoids, tissues and biofluids, together with the other members of the team. /p h3Your mission /h3 ul libDevelop and optimize advanced proteomics workflows /bbr/Establish robust protocols for spatial/visual, plasma and clinical proteomics, including bottom-up sample preparation pipelines and peptide enrichment strategies. /li libOperate and maintain mass spectrometry platforms /bbr/Perform instrument calibration, cleaning, basic maintenance, and support automation of peptide extraction, digestion, and cleanup for diverse sample types. /li libManage large-scale proteomics studies /bbr/Oversee processing and data acquisition for high-throughput projects involving hundreds to thousands of samples, ensuring quality and reproducibility. /li libAnalyze data and support facility users /bbr/Deliver and explain results to users, contribute to experimental design and project planning, provide technical support during projects, and train internal and external researchers. /li libContribute to the growth of the Unit /bbr/Support resource planning,



introduce new protocols and applications, collaborate with vendors and service engineers, mentor junior staff, and participate in facility reviews and research initiatives. /li libSupport facility operations and quality assurance /bbr/Manage facility digital platforms and software, support procurement and inventory monitoring, perform advanced troubleshooting of protocols and technical issues, contribute to the development and implementation of Standard Operating Procedures (SOPs) and quality assurance parameters for reporting and auditing. /li libSupport facility operations and quality assurance /bbr/Manage facility software, support procurement and inventory monitoring, perform advanced troubleshooting of protocols and technical issues. /li /ul h3Grow your skills /h3 pYou will enhance your scientific and professional skills by working with: /p ul libcutting-edge proteomics technologies /b, including state-of-the-art mass spectrometry platforms, automation, and advanced workflows for single-cell, spatial, and clinical proteomics. /li libcomplex experimental design and large-scale data generation /b, ensuring high-quality, reproducible results in a high-throughput facility environment. /li libmultidisciplinary collaboration and facility operations /b, developing expertise in project coordination, user support, technology development, and mentoring within a leading research infrastructure. /li /ul pHuman Technopole supports career development through training, mentoring and dedicated learning opportunities. /p h3What you'll bring /h3 ul liPhD in a relevant subject (e.g. biology, biotechnology, biochemistry, chemistry) to be obtained within the deadline of the call.



/li libOne or more /b of the following: experience with plasma proteomics, spatial/tissue proteomics, clinical proteomics, single cell proteomics /li liExperience with implementing mass spec/proteomics methods at the spectrometer. /li liFamiliarity with operating and troubleshooting LC-MS platforms. /li /ul h3Preferred /h3 h3Any one of the following: /h3 ul liExperience with DIA for global untargeted proteomics /li liFamiliarity with Astral, Hybrid or Tribrid Mass Spectrometers. /li liExperience in working with large cohorts and/or patient sample sets, including benchmarking and QC. /li liExperience in standardising workflows and/or developing targeted assays. /li liExperience with machine learning in proteomics data analysis. /li liExperience with spatial proteomics workflows /li /ul h3Organizational and social skills: /h3 ul liCommunication, team building and problem‑solving skills; /li liAbility to interact effectively with other teams and work synergistically to effectively drive projects. /li liHighly organised and meticulous work attitude. /li liMotivation to mentor and train. /li /ul h3At HT, your discoveries contribute to a global effort to improve human health. /h3 h3Why Human Technopole /h3 pHT offers an international and dynamic workplace, competitive welfare provisions, flexible working policies and relocation support. Researchers relocating to Italy may agevolazioni from attractive tax benefits. We promote work–life balance and provide parental support initiatives. /p pThis is a 3-year contract offered under CCNL Chimico Farmaceutico, Level B2 /p pSalary: up to € 52.000,00 depending on the candidate’ seniority.br/The position is based in Milan, Italy, within our vibrant international campus.br/bWe strongly encourage applications from candidates belonging to protected categories (L. 68/99). /b /p pInformation at a Glance Legal Entity: Fondazione Human Technopole Area: Scientific Operations Unit of Service: Scientific Facilities /p #J-18808-Ljbffr

📌 Proteomics Specialist (Milano)
🏢 Human Technopole
📍 Milano