Organisation/Company Politecnico di Torino Department DIMEAS Research Field Engineering » Aerospace engineering Engineering » Biomedical engineering Mathematics » Applied mathematics Researcher Profile First Stage Researcher (R1) Positions PhD Positions Application Deadline 10 Dec 2026 - 00:00 (Europe/Rome) Country Italy Type of Contract Temporary Job Status Full-time Offer Starting Date 1 Nov 2027 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
Offer Description Cardiovascular Deconditioning in Space Medicine: A Computational Approach to Investigate Mechanisms and Potential Countermeasures
Long-duration spaceflight induces cardiovascular adaptations, including cephalad fluid shift, changes in blood volume and venous return, and altered hemodynamic regulation. These responses contribute to cardiovascular deconditioning and may be associated with mission-relevant risks such as Spaceflight-Associated Neuro-ocular Syndrome (SANS) and venous thromboembolism (VTE).



The mechanisms linking altered gravity to systemic, cerebral, ocular, and venous hemodynamics remain incompletely understood.
This project will build on the group's existing closed-loop, multiscale 0D–1D cardiovascular model and its subsequent developments to investigate cardiovascular adaptation to altered gravity and the mechanisms underlying deconditioning. The framework will be extended to represent gravity- and posture-dependent processes, including venous collapse, pressure effects associated with lower-body negative pressure (LBNP), and gravity gradients and Coriolis forces during short-radius artificial gravity (AG). Where suitable data are available, model behavior will be evaluated against non-invasive measurements from ground-based analogues, including head-up/head-down tilt, water immersion, and centrifuge studies. The model will then be used to examine the potential physiological e

📌 CSC-Funded PhD Opportunity in Cardiovascular Deconditioning and Space Medicine (Italia)
🏢 Politecnico Di Torino
📍 Italia