ppProfessional | Permanent | Full-time | Hybrid /ppIf you're passionate about changing lives for the better, this is the opportunity you've been waiting for.
In bResearch Development /b, we're continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve.
You'll work with talented colleagues in a state-of-the-art Research Development environment, developing innovative medicines that change the life of patients for the better and help us make progress towards our vision of a world free of pain.
Join us today, and discover the difference you can make.
/ph3What The Job Looks Like /h3pEvery day you will enjoy different challenges such as: /pulliLead the design and computational optimisation of RNA therapeutics, particularly siRNA, integrating RNA biology with oligonucleotide chemistry to enable gene knockdown and RNA regulatory approaches, including up-regulation strategies.
/liliDefine and prioritise target sites and design strategies by integrating sequence features, RNA accessibility, transcript structure, cross-species alignment, and emerging experimental data /liliDrive iterative design–test–learn cycles by analysing and rapidly integrating datasets linking sequence, chemistry, and biological activity to inform decision-making /liliDevelop and apply computational tools and workflows (e.g. Python or R) to enable scalable oligonucleotide design, data integration, and rapid sequence–chemistry iteration /liliPartner closely with oligonucleotide chemists and delivery scientists to co-optimise sequence, chemical modifications, and delivery approaches to maximise potency, durability,



and tissue activity /liliLead and contribute to discovery programs advancing RNA therapeutic candidates toward candidate profiling and clinical development, while helping prioritise and evaluate new targets aligned with platform capabilities.
/li /ulh3What You'll Bring To The Table /h3pTo make the most of this role and truly thrive, you should have: /pulliPhD in RNA biology, molecular biology, computational biology, bioinformatics, or a related discipline /liliMore than 10 years of relevant industry experience, including at least 5 years in therapeutic antisense or siRNA design and optimisation /liliStrong computational skills, including experience developing scripts or workflows (e.g. Python or R) /liliExperience designing siRNA across CNS and systemic delivery contexts, including optimisation of sequence and chemistry for robust in vivo activity /liliProven track record contributing to or leading programs that progressed molecules to candidate stage, with demonstrated involvement in programs advancing toward clinical development /liliStrong understanding of oligonucleotide optimisation and risk assessment across discovery and development stages, from early design through to late-stage candidate selection /liliExperience delivering siRNA therapeutics in liver and CNS indications is highly desirable, ideally including progression of molecules toward clinical development /liliStrong scientific problem-solving mindset with a focus on delivering impact /liliAbility to operate effectively in a highly matrixed, cross-functional environment with a high degree of independence, ownership, and accountability /li /ulpb"Be part of a team redefining what's possible in genetic medicine, creating transformative RNA therapies for severe pain, neurological disease, and adjacent areas where we can extend the reach of our platforms." /b /ppKeith Geoffrey Phillips , the Hiring Manager /p /p #J-*****-Ljbffr

📌 Oligonucleotide Design Lead (F/M/D) (Bardi)
🏢 Grünenthal Group
📍 Bardi